Physiological Parameters Can Help Guide Heart Failure Therapy

Neuronal dysfunction and medical therapy in heart failure: can an imaging biomarker help to "personalize" therapy?

(123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging is a tool for evaluating one of the fundamental pathophysiologic abnormalities seen in heart failure (HF), that of an upregulated sympathetic nervous system and its effect on the myocardium. Although this imaging technique offers information about prognosis for patients treated with contemporary guideline-based HF therapies and improves risk ...

Natural Help for Congestive Heart Failure

While symptoms may not always be present, they tend to become most noticeable during physical exertion, as people often describe difficulty exercising, accompanied by feelings of fatigue and dizziness. As the heart struggles to pump sufficient blood to the body and blood pressure drops, the body tries to compensate by triggering hormone and nerve signals to increase the blood volume through wat...

Hemodynamic parameters to guide fluid therapy

The clinical determination of the intravascular volume can be extremely difficult in critically ill and injured patients as well as those undergoing major surgery. This is problematic because fluid loading is considered the first step in the resuscitation of hemodynamically unstable patients. Yet, multiple studies have demonstrated that only approximately 50% of hemodynamically unstable patient...

Can Experimental Economics Help Guide Restructuring of Electric Power?

Isoniazid treatment of children: can genetics help guide treatment?

H alf of the world’s population are children, yet many of the most important developments in drug therapy ignore the needs of this most vulnerable population. With Mycobacterium tuberculosis as the cause of one of the most important chronic infectious diseases worldwide, it is gratifying to see research that describes the integration of modern molecular techniques to improve the delivery of the...